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There are several matches for 'Long-chain-fatty-acid--CoA ligase'.
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7024 matches
showing page 1 of 352
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organism
protein
1)
Homo sapiens
SLC27A2 - Very long-chain acyl-CoA synthetase; Acyl CoA synthetase that activates long-chain and very long- chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl- CoA. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepati [...]
[a.k.a. NM_003645, CCDS53943, NP_001153101.1,
Long-chain-fatty-acid--CoA ligase
]
2)
Mus musculus
Slc27a2 - Very long-chain acyl-CoA synthetase; Acyl CoA synthetase that activates long-chain and very long- chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl- CoA. Can also activate branched- chain fatty acids such as phytanic acid and pristanic acid (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy- 5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Exhibits long-chain fatty acids (LCFA) transp [...]
[a.k.a. ENSMUSP00000057595, ENSMUST00000150947.1, AAH22170.1,
Long-chain-fatty-acid--CoA ligase
]
3)
Escherichia coli K12
fadD - acyl-
CoA
synthetase (
long
-
chain
-
fatty
-
acid
--
CoA
ligase
); Catalyzes the esterification, concomitant with transport, of exogenous
long
-
chain
fatty
acids
into metabolically active
CoA
thioesters for subsequent degradation or incorporation into phospholipids. Activity is the highest with
fatty
acid
substrates of > 10 carbon atoms. Is involved in the aerobic beta- oxidative degradation of
fatty
acids
, which allows aerobic growth of E.coli on
fatty
acids
as a sole carbon and energy source.
[a.k.a. b1805, AAC74875.1, Acyl-CoA synthetase,
Long-chain-fatty-acid--CoA ligase
]
4)
Homo sapiens
ACSBG2 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
ACSBG2; Catalyzes the conversion of
fatty
acids
such as
long
chain
and very
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated
fatty
acids
. Has increased ability to activate oleic and linoleic
acid
. May play a role in spermatogenesis.
[a.k.a. NM_001321384.1, PRTD-NY3, ACSBG2-207]
5)
Homo sapiens
ACSBG1 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
ACSBG1; Catalyzes the conversion of
fatty
acids
such as
long
-
chain
and very
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated
fatty
acids
; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
[a.k.a. ENST00000560817.5, 23205, hBG1]
6)
Homo sapiens
ACSL5 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
5; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate
fatty
acids
from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated
fatty
acids
with a preference for C16-C18 unsaturated
fatty
acids
(By similarity). It was suggested that it may also stimulate
fatty
acid
oxidation (By similarity). At the villus tip of the crypt-villus axis of the small [...]
[a.k.a. R-HSA-556833, HPA007162, ENST00000354655]
7)
Homo sapiens
ACSL3 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
3; Acyl-
CoA
synthetases (ACSL) activates
long
-
chain
fatty
acids
for both synthesis of cellular lipids, and degradation via beta- oxidation. Required for the incorporation of
fatty
acids
into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
[a.k.a. ENST00000264415, O95573, ENST00000392066.7]
8)
Homo sapiens
ACSL6 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
6; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoA
for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in
fatty
acid
metabolism in brain and the acyl-
CoAs
produced may be utilized exclusively for the synthesis of the brain lipid; Belongs to the ATP-dependent AMP-binding enzyme family.
[a.k.a. UPI0003EAF834, C9JPA5, ACSL6-214]
9)
Homo sapiens
ACSL1 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
1; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic
acids
(EETs) or hydroxyeicosatrienoic
acids
(HETEs) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family.
[a.k.a. B7Z452, XP_016863376.1, XM_011531742]
10)
Homo sapiens
ACSL4 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
4; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoA
for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family.
[a.k.a. UPI000016A488, ACSL4-202, NM_022977]
11)
Mus musculus
Acsbg2 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
ACSBG2; Catalyzes the conversion of
fatty
acids
such as
long
chain
and very
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated
fatty
acids
. Has increased ability to activate oleic and linoleic
acid
. May play a role in spermatogenesis.
[a.k.a. ENSMUSG00000024207, ENSMUST00000043062.4, 6.2.1.3]
12)
Mus musculus
Acsbg1 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
ACSBG1; Catalyzes the conversion of
fatty
acids
such as
long
-
chain
and very
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Can activate diverse saturated, monosaturated and polyunsaturated
fatty
acids
.
[a.k.a. Acyl-CoA synthetase bubblegum family member 1, Q99PU5, ENSMUST00000138315]
13)
Mus musculus
Acsl3 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
3; Acyl-
CoA
synthetases (ACSL) activates
long
-
chain
fatty
acids
for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of
fatty
acids
into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...]
[a.k.a. ENSMUST00000035779, AK161708, ENSMUST00000035779.14]
14)
Mus musculus
Acsl6 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
6; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoA
for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Plays an important role in
fatty
acid
metabolism in brain and the acyl-
CoAs
produced may be utilized exclusively for the synthesis of the brain lipid (By similarity).
[a.k.a. ENSMUST00000064690.9, NM_001033598, NM_001033599.1]
15)
Mus musculus
Acsl5 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
5; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL5 may activate
fatty
acids
from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate
fatty
acid
oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAI [...]
[a.k.a. ENSMUST00000224337.1, ENSMUST00000043150, ENSMUST00000163443]
16)
Mus musculus
Acsl1 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
1; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoAs
for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic
acids
(EETs) or hydroxyeicosatrienoic
acids
(HETEs); Belongs to the ATP-dependent AMP-binding enzyme family.
[a.k.a. ENSMUSP00000106001, AC138367, AK149406]
17)
Mus musculus
Acsl4 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
4; Catalyzes the conversion of
long
-
chain
fatty
acids
to their active form acyl-
CoA
for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family.
[a.k.a. BC016416, NM_001033600.1, Acsl4-203]
18)
Drosophila melanogaster
bgm - Very
long
-
chain
-
fatty
-
acid
--
CoA
ligase
bubblegum; Mediates activation of
long
-
chain
fatty
acids
for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function.
[a.k.a. FBgn0027348, bgm-PC, bgm-PA]
19)
Drosophila melanogaster
hll -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
heimdall; Mediates activation of
long
-
chain
fatty
acids
for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
[a.k.a. FBgn0286723, hll-PA, dbb]
20)
Saccharomyces cerevisiae
FAA1 -
Long
-
chain
-
fatty
-
acid
--
CoA
ligase
1;
Long
chain
fatty
acyl-
CoA
synthetase; activates
fatty
acids
with a preference for C12:0-C16:0
chain
lengths; role in the competitive import of
long
-
chain
fatty
acids
and sphingoid
long
-
chain
bases; accounts for most acyl-
CoA
synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4.
[a.k.a. YOR317W, 854495, UPI000012E287]
7024 matches
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